Administration
Scientific Counsil
How to reach us
History in short
Elevter Andronikashvili
News
Photo Gallery
Research Topics
Ongoing Grant
     Projects and Patents

Publications
Cell and DNA Physics
   - Researche
Thermal Properties of
     Complex Heterogeneous
     Biological Systems

   - Researche
Interaction of Nanoparticles
     with DNA

   - Researche
Organism Protection Systems
   - Researche
   - Researche

          

DEPARTMENT OF BIOLOGICAL SYSTEM
PHYSICS

Cell and DNA Physics


Study influence of (Lis-Gly), (Ala-Glu-Asp-Gly) and (Ala-Glu-Asp-Leu) bioregulators on chromatin and nuclei in solutions and chromatin in situ, as well as influence of Cu(II)TOEPyP on DNA; determination of molecular mechanizm on the base of thermodinamic parameters (ΔHm, ΔSm, Tm, ΔTm)  caused by this interaction.

Influence of a newly Synthesized anticarcinogen TMPy(4) tetramethil pyridil porphirine analogue Cu(II)TOEPyP(4) on DNA thermodynamic parameters have been studied. It is shown that the compound preferably binds to GC reach sites, it stabilizes DNA and mild (treatment) concentrations of it does not cause any harm to the double helix, which is very important in pharmacology.

It is shown that the melting process has entropic and not enthalpic character.

Team leader: J. Monaselidze, Leading Scientist
Team members: M. Gorgoshidze, D. Khachidze, M. Kiladze, E. Lomidze, Sh. Barbakadze

Differential scanning microcalorimetry study of breast cancer and leukemia blood plasma and erythrocytes thermal characteristics.

Mammary gland duct carcinoma biopsy tissue microcalorimetric investigation has shown that collagen type IV fibrils have a critical role in stability of epithelia cell matrix. It was determined that stability of collagen type IV fibrils is decreased by 6 degrees in comparison with norm Stability of carcinoma epithelia cells is also decreased in comparison to the norm. Namely, stability of heterochromatin is decreased by 4 degrees, and stability of active chromatin is decreased by 3 degrees. We offer to use these data for patient diagnosis.

Human leukemia blood plasma calorimetry study has demonstrated that albumin thermostability in leukemia blood composition is increased by 5-6 degrees in comparison to the norm. These data are obtained after examination of more than 300 samples. We offer to use these data to determine the first stage of leukemia.

Calorimeters used in these studies are equipped with software used for calculation of thermodynamic parameters in solutions and complex biological systems, as well as for data processing, including deconvulation.

Team leader: J. Monaselidze, Leading Scientist
Team members: M. Gorgoshidze, D. Khachidze, M. Kiladze, E. Lomidze, Sh. Barbakadze, Z. Kuchadze